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By D. M. Jerina, J. M. Sayer, D. R. Thakker (auth.), Bernard Pullman, Paul O. P. Ts’o, Harry Gelboin (eds.)

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Read Online or Download Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 28 – May 2, 1980 PDF

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Additional info for Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 28 – May 2, 1980

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Siophys. Res. Cornrnun. 88, pp. 688-695. 24. Osborne, M. , Harvey, R. : Interact. 20, pp. 123-130. 25. Harvey, R. : 1980, "Safe Handling of Chemical Carcinogens, Mutagens, Teratogens, and Highly Toxic Substances", Walters, D. , Vol. 2, Chap. 23, pp. 439-468. -Biol. DIHYDRODIOLS AND DIOL-EPOXIDES IN THE ACTIVATION AND DETOXIFICATION OF POLYCYCLIC HYDROCARBONS Peter Sims Chester Beatty Research Institute, Institute of Cancer Research:Royal Cancer Hospital, Fulham Road, London SW3 6JB, England. ABSTRACT The weak carcinogen, benz (a) anthracene, is metabolized to a number of dihydrodiols and diol-epoxides.

1975) on its further metabolism, using glutathione as a trapping agent, indicated that metabolism probably occurred on the 8,9-bond, presumably through the formation of the non-vicinal 5,6-diol-8,9-epoxide, which could then yield the 5,6,8,9-tetrahydrotetrol by hydration of the epoxide ring. The 8,9-dihydrodiol is metabolized mainly to the antiisomer of the 8,9-diol-10,11-epoxide (Sims and Grover, 1976), although 36 P. , 1975). S. -Early studies by Swaisland et al. (1974), using Sephadex LH20 chromatography, of the nucleoside-adducts obtained from the hydrolysis of DNA of hamster embryo cells treated with benz(a)anthracene indicated that an 8,9-diol-10,11-epoxide might be involved in the metabolic activation of the hydrocarbon.

Chern. 45, pp. 169-171. 21. Lee, H. M. and Harvey, R. : 1980, J. Org. Chern. 45, pp. 588-592. 22. Hsu, W. , Lin, E. , Fu, P. , Harvey, R. , and Weiss, S. : 1979, Biochern. Biophys. Res. Cornrnun. 88, pp. 251-257. 23. Chang, G. , Harvey, R. , Hsu, W. , and Weiss, S. : 1979, Biochern. Siophys. Res. Cornrnun. 88, pp. 688-695. 24. Osborne, M. , Harvey, R. : Interact. 20, pp. 123-130. 25. Harvey, R. : 1980, "Safe Handling of Chemical Carcinogens, Mutagens, Teratogens, and Highly Toxic Substances", Walters, D.

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