New PDF release: Brain Tumors in Adults, An Issue of Neurologic Clinics

By Patrick Wen MD, David Schiff MD

In 2007, among 40.000 and 50,000 humans within the usa might be clinically determined with fundamental mind tumors, nearly all of whom might be adults. 3 times this quantity will advance metastatic mind tumors from melanoma originating in other places within the physique. This factor of Neurologic Clinics comprises the next articles: Epidemiology of mind Tumors (Wrensch, Claus); Molecular Pathogenesis of mind Tumors and the function of Stem Cells (Ligon, Kesari); Advances in Neuroimaging of mind Tumors (Henson); clinical administration of mind Tumor sufferers (Schiff, Wen); Advances in Neurosurgery for mind Tumors (Shaffrey); Advances in Radiation remedy for mind Tumors (Mehta); Novel remedies for mind Tumors (Wen, Schiff); Anaplastic Astrocytomas and Glioblastomas (Reardon); Anaplastic Oligodendrogliomas and Anaplastic Oligoastrocytomas (Van Den Bent); Low-Grade Gliomas (Lang, Gilbert); mind Metastases (Deangelis); Benign mind Tumors (Link); fundamental CNS Lymphoma (Abrey); and Genetic motives of mind Tumors (Plotkin).

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Response of asymptomatic brain metastases from small-cell lung cancer to systemic first-line chemotherapy. J Clin Oncol 2006;24(13): 2079–83. [69] Kollmannsberger C, Nichols C, Bamberg M, et al. First-line high-dose chemotherapy þ/À radiation therapy in patients with metastatic germ-cell cancer and brain metastases. Ann Oncol 2000;11(5):553–9. [70] Cocconi G, Lottici R, Bisagni G, et al. Combination therapy with platinum and etoposide of brain metastases from breast carcinoma. Cancer Invest 1990;8(3–4):327–34.

Int J Radiat Oncol Biol Phys 2006;64(4):1023–30. [81] Meyers CA, Smith JA, Bezjak A, et al. Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial. J Clin Oncol 2004;22(1):157–65. Neurol Clin 25 (2007) 1141–1171 Novel Therapies for Malignant Gliomas Robert Cavaliere, MDa,*, Patrick Y. Wen, MDb, David Schiff, MDc a Division of Neuro-Oncology, Ohio State University, 463 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA b Center For Neuro-Oncology, Dana-Farber/Brigham and Women’s Cancer Center, SW430D, 44 Binney Street, Boston, MA 02115, USA c Neuro-Oncology Center, University of Virginia Health Science Center, Box 800432, Charlottesville, VA 22908-0432, USA The blood-brain barrier effectively separates systemic circulation from the central nervous system (CNS), thereby creating a sanctuary within the CNS.

54] Jacquillat C, Khayat D, Banzet P, et al. Final report of the French multicenter phase II study of the nitrosourea fotemustine in 153 evaluable patients with disseminated malignant melanoma including patients with cerebral metastases. Cancer 1990;66(9):1873–8. [55] Rosner D, Nemoto T, Lane WW. Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer 1986;58(4):832–9. BRAIN METASTASES 1191 [56] Oberhoff C, Kieback DG, Wurstlein R, et al. Topotecan chemotherapy in patients with breast cancer and brain metastases: results of a pilot study.

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