New PDF release: Biologic Therapy of Leukemia (Contemporary Hematology)

By Matt Kalaycio

Intriguing new "biologic" cures for treating leukemia are showing so speedily that clinicians usually locate it tough to make trained judgements approximately their use whilst making sufferer therapy judgements. Biologic treatment of Leukemia summarizes and experiences the entire on hand info touching on those state of the art biologic cures in order that practising clinicians could make the right kind patient-care offerings. right here the busy medical professional will locate in a single handy position the most important details at the makes use of and obstacles of the key biologic remedies for leukemia, different biologic recommendations for its remedy, the administration of sufferers being handled with such biologic brokers, and the present and destiny position of rising biologic brokers.

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Extra resources for Biologic Therapy of Leukemia (Contemporary Hematology)

Example text

One would then infuse donor hematopoietic cells and rely entirely on the GVT effect to generate a tumor response. This is the fundamental concept of nonmyeloablative (“mini”) allogeneic transplantation. To summarize, the rationale is straightforward: 1. Some malignancies will not be cured by high-dose chemotherapy. 2. Some malignancies may be cured by the GVT effect. 3. If so, a minimal BMT preparative regimen would be desirable to prevent graft rejection and minimize toxicity. 4. Once the donor cells engraft, a GVT effect will hopefully result, leading to a clinical remission.

Investigators at Cambridge Pathology developed the first rat anti-CD52 antibody, CAMPATH-1M. This MAb-induced complement-mediated cytotoxicity in vitro but had little clinical activity (38). A subsequent rat MAb, CAMPATH1G, induced ADCC and could deplete lymphocytes from the circulation in vivo (39). Finally, a genetically reshaped human IgG1 CD52 MAb, CAMPATH-1H or alemtuzumab, was developed that mediates ADCC and demonstrates clinical activity. Alemtuzumab is a powerful immunosuppressant and effectively eliminates circulating lymphocytes.

30. Glass B, Uharek L, Zeis M, et al. Graft-versus-leukaemia activity can be predicted by natural cytotoxicity against leukaemia cells. Br J Haematol 1996;93:412–420. 31. Tsukada N, Kobata T, Aizawa Y, Yagita H, Okumura K. Graft-versus-leukemia effect and graftversus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 1999;93:2738–2747. 32. Weiss L, Weigensberg M, Morecki S, et al. Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia.

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