By Shaker A. Mousa
1This selection of assessment articles highlights the newest improvement of antithrombotics and offers confirmed experimental tools for the extra improvement of recent and more desirable anticoagulants. one of the state of the art advancements reviewed are the radical utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medicinal drugs because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra suggestions mentioned contain aspirin and clopidogrel, the multiplied use of polytherapeutic techniques, antiproteases (factors IIa, Xa, and VIIa), tissue issue concentrating on, platelet receptor concentrating on, and antithrombin III modulation.
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Additional resources for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine)
Biol. 21, 149–156. Turner, N. , Moake, J. , Kamat, S. , Schafer, A. , Kleiman, N. , and McIntire, L. V. (1995) Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glycoprotein IIb-IIIa. Circulation 91, 1354–1362. Mousa, S. , Abulencia, J. , McCarty, O. J. , Turner, N. , and Konstantopoulos, K. (2002) Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis.
1. 3. outline the procedure for isolation and purification of platelets from whole blood obtained by venipuncture from human volunteers. 1. 38% final concentration) or heparin (10 U/mL final concentration) (19). 2. Preparation of Platelet-Rich Plasma Centrifuge anticoagulated whole blood at 160g for 15 min to prepare plateletrich plasma (PRP) (see Note 1). 3. Isolation of Washed Platelets 1. PRP specimens are subjected to a further centrifugation (1,100g for 15 min) in the presence of 2 µM PGE1 (22).
Alevriadou, B. , Moake, J. , Turner, N. , Ruggeri, Z. , Folie, B. , Phillips, M. , et al. (1993) Real-time analysis of shear dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 81, 1263–1276. 6. Turitto, V. T. (1982) Blood viscosity, mass transport, and thrombogenesis. Prog. Hemostasis Thromb. 6, 139–177. 7. The EPIC Investigators (1994) Use of a monoclonal antibody directed against the glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty.