By Wojciech Gorczyca
This wide reference masking neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors concerning lymph nodes, spleen, bone marrow, and ordinarily affected extranodal organs, with specific emphasis at the differential prognosis. It discusses uncomplicated medical, prognostic, morphologic and phenotypic information, with a variety of tables summarizing the phenotypic profiles of the most typical hematologic tumors. a huge function of this ebook is an method of hematologic tumors in response to the WHO class, with correct examples and emphasis at the most beneficial morphologic and immunophenotypic beneficial properties utilized in diagnosis.It might be a useful reference for all practicing hematologists, oncologists and pathologists.
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Extra info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
Bright staining is at least two log decades brighter than negative control. 11C) display bright expression of CD11c and CD3, respectively. 11D shows B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL; green) with dim expression of CD20 (x-axis) and positive expression of lambda immunoglobulins (y-axis). As illustrated, FC gives information about the presence or absence of a given antigen as well as its intensity of expression. Dim expression of CD20 and surface light-chain immunoglobulin is characteristically seen in B-chronic lymphocytic leukemia/ small lymphocytic lymphoma.
The red pulp is composed of arterioles, sinusoids and venules. Numerous erythrocytes are responsible for its red color. The sinuses are lined by littoral cells, cells with dual endothelial/macrophage function (they are also present in the medullary sinuses of lymph node). , CD31) as well as histiocyte/macrophage marker CD68. 31 present an algorithmic approach to the possible diagnosis of lymphoma, CML, plasma cell myeloma and anemia/MDS, respectively. 12 presents the current WHO classification of the hematolymphoid tumors72–87.
Monosomies and trisomies). 11 present common chromosomal changes in hematopoietic tumors. 21 shows examples of PCR studies. NORMAL STRUCTURE OF HEMATOLYMPHOID ORGANS The hematolymphoid system, in which leukemia and lymphoma arise, consists of lymph nodes, the bone marrow, the spleen and the thymus. Atlas of differential diagnosis in neoplastic hematopathology 40 Lymph node The lymph nodes act as a scaffolding system and home for lymphocytes and monocytes/histiocytes in the lymphatic system. 22A).