New PDF release: Advances in Brain Imaging

By John M. Morihisa

Albany scientific collage, Albany, long island. deals clinicians and researchers greater realizing of the speculation and perform of mind imaging in psychiatry. experiences purposes to such problems as melancholy, obsessive-compulsive illness, and schizophrenia. Softcover. DNLM: psychological issues - analysis.

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Psychol Med 29:997–1002, 1999 O’Rourke DH, Gottesman II, Suarez BK, et al: Refutation of the general single-locus model for the etiology of schizophrenia. Am J Hum Genet 34(4):630–649, 1982 Phillips ML, Williams L, Senior C, et al: A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatric Research: Neuroimaging 92(8):11–31, 1999 Piercy M: The effects of cerebral lesions on intellectual function: a review of current research trends.

The term executive functions refers to the set of cognitive operations required to maintain organized information and coordinated actions in the brain. The neural systems supporting executive control appear to be uniquely sensitive to the effects of psychiatric disease. A detailed account of the contributions of subregions of the frontal cortex to executive functions, based on recent event-related fMRI studies performed in our laboratory, will be described, together with a discussion of how abnormal physiology in these regions is likely to be associated with two common serious mental disorders, schizophrenia—a disorder of undercontrol—and obsessive-compulsive disorder (OCD)—a disorder of overcontrol.

However, the clinical significance of cognitive deficits in schizophrenia has only recently been systematically examined. In a number of studies, cognitive dysfunction in schizophrenia has been shown to be related to behavioral disorganization (Barch and Carter 1998; Cohen et al. 1999; Green 1998; Liddle and Morris 1991), providing some support for the Bleulerian view. Most importantly, cognitive dysfunction is a strong predictor of poor outcome (Green 1996, 1998; Weinberger and Gallhofer 1997), more robustly so than hallucinations and delusions.

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